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In a hilarious yet unexpected twist, Lizzo found herself the center of attention in a South Park episode. The show’s latest special, South Park: The End of Obesity, which premiered on May 24, took on the hot topic of weight loss drugs like Ozempic. And guess what? They named a faux alternative after Lizzo herself.

A day after the episode aired, Lizzo, 36, shared her reaction on TikTok in a “blind duet” video. “Guys, my worst fear has been actualized. I’ve been referenced in a South Park episode,” she started, looking genuinely surprised.

“I’m so scared,” she continued, clearly bracing for what was coming next. The scene kicked off with a conversation between Sharon and Sheila, the moms of main characters Stan and Kyle. Sharon reveals that her doctor won’t prescribe weight loss meds like Ozempic because she doesn’t have diabetes. Sheila, curious, asks how she manages her weight without them.

“Don’t you know, Sheila?” Sharon says. “Now, there’s a whole new obesity drug for those of us who can’t afford Ozempic and Mounjaro. I controlled all my cravings to be thinner with Lizzo.”

Lizzo’s jaw dropped, and she covered her mouth in disbelief. The show then launched into a parody of those upbeat medication commercials, complete with a narrator explaining that this fake drug, Lizzo, “makes you feel good about your weight — and it costs 90% less than Ozempic.”

Lizzo couldn’t hide her shock as Sharon chimed in, “I’ve lowered my standards and my expectations.” The singer’s hand remained firmly planted over her mouth, still processing the absurdity of it all.


The ad claimed that the medication allows users to eat whatever they want with minimal exercise and that “70% of patients on Lizzo no longer care how much they weigh.” When the ad cut to a character listening to a Lizzo album, she exclaimed, “Not the f—— album!”

Sharon wrapped up the bit by saying, “Ask about the power of not giving a f— with Lizzo,” to which Lizzo responded with a snap and a “period.”

After the clip ended, Lizzo reflected on the surreal experience. “That’s crazy. I just feel like damn, I’m really that b—-. I really showed the world how to love yourself and not give a f—.”

Referring to South Park creators Trey Parker and Matt Stone, she added, “to the point where these men in Colorado know who the f— I am, and put it on their cartoon that’s been around for 25 years.”

“And I’m gonna keep on showing you how to not give a f—,” Lizzo concluded, ending her video with a cheeky nod to the faux ad’s jingle.

South Park: The End of Obesity is now streaming on Paramount+.

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